Cystatin C

[Cystatin C and cardiovascular risk].

Patients with chronic kidney disease (CKD) are at high risk for developing cardiovascular disease (CVD) and cardiovascular events. Cystatin C, a protease inhibitor synthesized in all nucleated cells, has been proposed as a replacement for serum creatinine for the assessment of renal function, particularly to detect small reductions in glomerular filtration rate. This report presents a review of...

Cystatin C in Alzheimer's disease

Changes in expression and secretion levels of cystatin C (CysC) in the brain in various neurological disorders and in animal models of neurodegeneration underscore a role for CysC in these conditions. A polymorphism in the CysC gene (CST3) is linked to increased risk for Alzheimer's disease (AD). AD pathology is characterized by deposition of oligomeric and fibrillar forms of amyloid β (Aβ) in ...

Cystatin C and Cardiovascular Disease

BACKGROUND Epidemiological studies show that high circulating cystatin C is associated with risk of cardiovascular disease (CVD), independent of creatinine-based renal function measurements. It is unclear whether this relationship is causal, arises from residual confounding, and/or is a consequence of reverse causation. OBJECTIVES The aim of this study was to use Mendelian randomization to in...

Renal extraction of cystatin C.

Cystatin C is considered as a new marker of glomerular filtration rate (GFR). However, studies on its renal physiological handling are lacking [1], making the study of van Rossum et al. interesting [2]. Nevertheless, we have some comments. Firstly, as contrast injection may induce acute variation in intrarenal haemodynamics, it would be of interest to know the timing of the sampling procedure i...

Cystatin C versus creatinine in renovascular disease.